The ministry of health declared an Ebola epidemic in the N’Zerekore region of Guinea on 14 February, following seven confirmed cases and three deaths. US government agencies are closely monitoring the epidemic, and coordinating with the Guinea government, the World Health Organisation, and other partners to provide rapid, localised outbreak control. This outbreak follows a declaration of an outbreak on 7 February by the DRC’s minister of health. The previous West African outbreak in 2014-16 killed over 11,300. The source of infection is under investigation. It is important to monitor one’s health for 21 days after travelling to an area experiencing an Ebola outbreak.